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- 220127-57-1
- 伊马替尼甲磺酸盐,>98.0%(HPLC)
伊马替尼甲磺酸盐,>98.0%(HPLC)
Imatinib Mesylate
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中文名称:
伊马替尼甲磺酸盐
英文名称:
Imatinib Mesylate
CAS No.:
220127-57-1
分子式:
C₃₀H₃₅N₇O₄S
分子量:
589.71
性状:
白色结晶粉末
密度:
0.858 g/mL at 25 °C(lit.)
熔点:
214-224°C
沸点:
133-134 °C(lit.)
闪点:
64°F
溶解性:
DMSO:59 mg/mL (100 mM)
保存条件:
RT
InChIKey:
YLMAHDNUQAMNNX-UHFFFAOYSA-N
InChI:
InChI=1S/C29H31N7O.CH4O3S/c1-21-5-10-25(18-27(21)34-29-31-13-11-26(33-29)24-4-3-12-30-19-24)32-28(37)23-8-6-22(7-9-23)20-36-16-14-35(2)15-17-36;1-5(2,3)4/h3-13,18-19H,14-17,20H2,1-2H3,(H,32,37)(H,31,33,34);1H3,(H,2,3,4)
Pubchem ID:
危化品级别:
GHS符号:

危害声明:
H302
关于的化合物详细属性等信息,点击“220127-57-1”
甲磺酸伊马替尼用途是什么?
提问时间:2021/8/19 9:09:35
甲磺酸伊马替尼是做什么用的?哪里可以用到甲磺酸伊马替尼?
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回复内容:
1
admin2021-08-19 09:09:35
甲磺酸伊马替尼抗肿瘤药物;一种酪氨酸激酶抑制剂,可抑制c-Kit、Bcr-Abl和PDGFR(IC50:100nM)。Imatinib mesylate is the mesylate salt of imatinib, a tyrosine kinase inhibitor with antineoplastic activity. Imatinib binds to an intracellular pocket located within tyrosine kinases (TK), thereby inhibiting ATP binding and preventing phosphorylation and the subsequent activation of growth receptors and their downstream signal transduction pathways. This agent inhibits TK encoded by the bcr-abl oncogene as well as receptor TKs encoded by the c-kit and platelet-derived growth factor receptor (PDGFR) oncogenes. Imatinib is used for chronic myelogenous leukemia (CML) and acute lymphocytic leukemia (ALL) that are Philadelphia chromosome-positive (Ph+) and certain types of gastrointestinal stromal tumors (GIST), systemic mastocytosis, and myelodysplastic syndrome.
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