Recombinant Mouse CD33/Siglec-3/Siglec3,BR

别名： CD33;Myeloid cell surface antigen CD33;Sialic acid-binding Ig-like lectin 3;Siglec-3;Siglec3
规格: 10ug ; 50ug ; 500ug ; 1mg
外观(性状)： Lyophilized from a 0.2 μm filtered solution of 20mM PB,150mM NaCl,pH7.4.
纯度: ≥90% as determined by reducing SDS-PAGE.
储存条件: Lyophilized protein should be stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days. Aliquots of reconstituted samples are stable at ≤ -20°C for 3 months.

背景说明： Mouse myeloid cell surface antigen CD33(CD33) is a member of the immunoglobulin superfamily and SIGLEC (sialic acid binding Ig-like lectin) family.CD33 contains one Ig-like C2-type domain and one Ig-like V-type domain.CD33 is a putative adhesion molecule of myelomonocytic-derived cells that mediates sialic-acid dependent binding to cells.CD33 preferentially binds to alpha-2，6-linked sialic acid.The sialic acid recognition site may be masked by cis interactions with sialic acids on the same cell surface.In the immune response，CD33 may act as an inhibitory receptor upon ligand induced tyrosine phosphorylation by recruiting cytoplasmic phosphatase(s) via their SH2 domain(s) that block signal transduction through dephosphorylation of signaling molecules.CD33 induces apoptosis in acute myeloid leukemia.CD33 is becoming increasingly important as a target of antibody-mediated therapy in acute myeloid leukaemia (AML).
来源： Human Cells

溶剂: Always centrifuge tubes before opening.Do not mix by vortex or pipetting.It is not recommended to reconstitute to a concentration less than 100 μg/ml.Dissolve the lyophilized protein in distilled water.Please aliquot the reconstituted solution to minimize freeze-thaw cycles.
内毒素: Less than 0.1 ng/ug(1 EU/ug)as determined by LAL test.

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