猪骨形态发生蛋白6检测yabo官网手机版 盒,BR

中文名称： 猪骨形态发生蛋白6检测yabo官网手机版 盒
英文名称： Porcine BMP6 ELISA Kit
别名： BMP6; BMP-6; vegetal related growth factor (TGFB-related); vegetal-related (TGFB related) cytokine; VG-1-R; VG-1-related protein; Vg1-related sequence; VGR; VGR1; Vgr-1
储存条件： 2-8℃，6 months
规格： 96T ; 48T
检测目标： BMP6
样品类型： 血清/血浆/细胞培养上清
反应性： Porcine
应用： ELISA
定量/定性： 定量检测
检测范围： 93.75-6000pg/mL
灵敏度： 46.875pg/mL
精密度： 板内，板间变异系数均<10%
回收率： 80%-120%

背景说明： Bone morphogenetic protein 6 (BMP6) is a protein that in humans is encoded by the BMP6 gene.[1][2] The protein encoded by this gene is a member of the TGFβ superfamily. Bone morphogenetic proteins (BMPs) are known for their ability to induce the growth of bone and cartilage. BMP6 is able to induce all osteogenic markers in mesenchymal stem cells. The BMPs are a family of secreted signaling molecules that can induce ectopic bone growth. BMPs are part of the transforming growth factor-beta (TGFB) superfamily. BMPs were originally identified by an ability of demineralized bone extract to induce endochondral osteogenesis in vivo in an extra skeletal site. Based on its expression early in embryogenesis, the BMP encoded by this gene has a proposed role in early development. In addition, the fact that this BMP is closely related to BMP5 and BMP7 has led to speculation of possible bone inductive activity. As of April 2009, an additional function of BMP6 has been identified as described in Nature Genetics April; 41 [4]:386-8. BMP6 is the key regulator of hepcidin, the small peptide secreted by the liver which is the major regulator of iron metabolism in mammals. BMP6 is expressed in normal and atherosclerotic smooth muscle cells,[3] normal and malignant prostatic tissue,[4] healthy and osteoarthritic human articular chondrocytes and can stimulate matrix synthesis in vitro.[5] Bone morphogenetic proteins 2 and 6, expressed in arthritic synovium, are regulated by proinflammatory cytokines and differentially modulate fibroblast-like synoviocyte apoptosis.[6]

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