Recombinant Human CD28/TP44,BR

别名： CD28;CD28 antigen;CD28 molecule;T-cell-specific surface glycoprotein CD28;Tp44;TP44
规格: 10ug ; 50ug ; 500ug ; 1mg
外观(性状)： Lyophilized from a 0.2 μm filtered solution of PBS, pH7.4.
纯度: ≥95% as determined by reducing SDS-PAGE.
储存条件: Powder:＜-20℃ for long store;RT，3 weeks.Liquid:4-7℃，2-7 days;＜-20℃，3 months.
运输条件： The product is shipped at ambient temperature.

背景说明： T-cell-specific surface glycoprotein CD28(CD28) is a single-pass typeI membrane protein which contains one Ig-likeV-type (immunoglobulin-like) domain.It belongs to the immunoglobulin(Ig) superfamily.CD28 is one of the molecules expressed on T cells that provide co-stimulatory signals，which are required for T cell activation.CD28 co-stimulation is necessary for CD4 positive T-cell proliferation and survival，interleukin-2 production，and T-helper type-2 development.Human post-thymic regulatory T cells require CD28 co-stimulation to expand and maintain potent suppressive function in vivo.Apoptosis plays a key role in the age-related decline of CD28 expression and in immunosenescence.CD28 is the receptor for CD80 (B7.1) and CD86 (B7.2).When activated by Toll-like receptor ligands，the CD80 expression is upregulated in antigen presenting cells (APCs).The CD86 expression on antigen presenting cells is constitutive.CD28 is the only B7 receptor constitutively expressed on naive T cells.
来源： Human cells

溶剂: Always centrifuge tubes before opening.Do not mix by vortex or pipetting.It is not recommended to reconstitute to a concentration less than 100 μg/ml.Dissolve the lyophilized protein in ddH2O.Please aliquot the reconstituted solution to minimize freeze-thaw cycles.
内毒素: Less than 0.1 ng/ug(1 IEU/ug)as determined by LAL test.

Recombinant Human T-cell-specific surface glycoprotein CD28 is produced by our Mammalian expression system and the target gene encoding Asn19-Pro152 is expressed with a Fc tag at the C-terminus.

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